Efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on activities of daily living in severe Alzheimer’s disease

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Efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on activities of daily living in severe Alzheimer’s disease

OBJECTIVE Investigate efficacy of 13.3 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease on Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale-Severe Impairment Version items and domains. METHODS Retrospective analysis of the 24-week, randomized, double-blind ACTivities of daily living and cognitION (ACTION) study, using factor analysis to establish "b...

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Efficacy of rivastigmine transdermal patch on activities of daily living: item responder analyses.

OBJECTIVE In Alzheimer's disease (AD), rivastigmine has demonstrated statistically significant efficacy versus placebo on cognition and activities of daily living (ADL). The aim of this retrospective analysis was to further evaluate the treatment effects of rivastigmine on individual ADL items. METHODS This exploratory analysis focused on the Alzheimer's Disease Cooperative Study Activities o...

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15 صفحه اول

A 24-Week, Randomized, Controlled Trial of Rivastigmine Patch 13.3 mg/24 h Versus 4.6 mg/24 h in Severe Alzheimer's Dementia

AIMS The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome measures were as follows: Severe Impairment Battery (SIB) and AD Cooperative Stu...

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High-dose 13.3mg/24h rivastigmine transdermal patch demonstrates efficacy on instrumental activities of daily living: analysis of autonomy and higher-level function subscales

cancelled P2035 Epigenetic mechanisms in a rare case of monozygotic twins discordant for Alzheimer’s disease C. D’Addario1, B. Arosio2, A. Di Francesco1, C. Abbate2, A. Casè3, L. Bergamaschini3,4, D. Mari2, M. Maccarrone1,5 1Biomedical Sciences, University of Teramo, Teramo, 2Geriatric Unit, Department of Clinical Sciences and Community, 3A.S.P. Pio Albergo Trivulzio, 4Medical Sciences, Univers...

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ژورنال

عنوان ژورنال: SAGE Open Medicine

سال: 2014

ISSN: 2050-3121,2050-3121

DOI: 10.1177/2050312114561569